2017.12.6 Version 3.1
Connections between genes in the gene regulatory were constructed based on the interactions of their coding products, that is, the protein-protein interactions(PPIs). The PPIs with highest confidence (interaction score bigger than or equal to 0.900) from the latest version of database STRING (1) were utilized to construct gene-gene pairs.
1. Szklarczyk, D., Morris, J.H., Cook, H., Kuhn, M., Wyder, S., Simonovic, M., Santos, A., Doncheva, N.T., Roth, A., Bork, P. et al. (2017) The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res, 45, D362-D368.
2017.9.15 Version 3.0
Guo, L. and Wang, J. (2017) rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks. Nucleic Acids Res. PMID: 29140525
2015.9.11 Version 2.0
Guo, L., Du, Y., Qu, S. and Wang, J. (2016) rVarBase: an updated database for regulatory features of human variants. Nucleic Acids Res, 44, D888-893. PMID: 26503253
2013.8.15 Version 1.0
Guo, L., Du, Y., Chang, S., Zhang, K. and Wang, J. (2014) rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42, D1033-1039. PMID: 24285297